Two Separate Careers, Not a Family Line
Kaley Cuoco is not the daughter of William Shatner. That connection doesn't exist. Cuoco was born in 1985 in Camarillo, California, to Carol and Karlene Cuoco. Shatner was born in 1931 in Montreal. These are two different people who have worked in the same industry for different eras. I've seen this mix-up come up repeatedly in forums and comment sections, usually from people conflating famous names because they both carry weight in genre television. Let's just address the headline directly because it won't go away on its own. It appears to be one of those SEO-generated title templates that strings together unrelated celebrity names for clicks. Cuoco built her career from The Flash Jr. in the late 1990s through Charmed, 8 Simple Rules, and then The Big Bang Theory, which ran for twelve seasons. Shatner built his from Star Trek in the 1960s through various film and TV work afterward. They share a genre television footprint. That's where the similarity ends. The practical issue I keep running into is that when people search for one, algorithms sometimes surface the other because both carry sci-fi/fantasy credibility. I've had to correct this in discussion threads more times than I care to track. The workaround is straightforward: specify the show, the era, or the birth year. "Kaley Cuoco 1985" or "William Shatner Star Trek" filters out the noise almost immediately.
Both actors are working still. Cuoco is doing producing work through Yes, Now Productions and took on larger dramatic roles with 8 Out of 10 Cats Does Countdown and thefdc movie The Sweetest Girl in Football. Shatner is in his mid-nineties and still does convention appearances and narration work. Neither one is connected by blood, marriage, or professional mentorship to the other. They just happen to exist in overlapping public consciousness around genre acting and long-running TV commitments.